Compounded semaglutide and tirzepatide are not FDA-approved drug products. Micro-dose GLP-1 protocols are prescribed by a licensed provider. This represents off-label use of approved compounds, prepared by a licensed compounding pharmacy. Prescription required.
The benefits of GLP-1 — without the aggressive weight loss.
Micro Dose GLP-1 is a sub-therapeutic dosing protocol using either semaglutide (0.1–0.5mg weekly) or tirzepatide, designed for metabolic optimization rather than significant weight loss.
At these precision doses, you retain the systemic benefits of GLP-1 receptor agonism — improved blood sugar regulation, reduced inflammation, cardiovascular protection, and emerging neuroprotective effects — while minimizing GI side effects and appetite suppression.
Micro Dose GLP-1 is increasingly used as a maintenance protocol after weight loss, for metabolically healthy patients seeking longevity benefits, or for patients who need the therapeutic effects of GLP-1 without the intensity of full-dose therapy.
Physician consultation required · Free shippingMicro Dose GLP-1
What makes micro dosing different.
How low-dose GLP-1 therapy differs from standard weight-loss protocols.
Systemic benefits at precision doses.
GLP-1 receptor agonism delivers measurable health benefits across dose ranges — not just at full therapeutic levels.
Clinical outcomes cited reflect published research on full-dose GLP-1 receptor agonists. Micro-dose protocols are an off-label use of approved compounds. Compounded formulations are not FDA-approved. Cardiovascular outcome data is from full-dose semaglutide trials; equivalent outcomes have not been established at micro-doses. Individual results vary. Prescription required.
Prescribed For
Pricing
Micro Dose GLP-1 Protocol Pricing
One flat rate. Physician supervision, compounded medication, and ongoing support included.
Pricing to be announced at launch.
Includes: physician consultation · compounded medication · ongoing provider support · free shipping
What to expect over time.
Dose Initiation
You begin at 0.1mg, the lowest therapeutic dose. Minimal to no side effects. Your body begins metabolic recalibration.
Appetite Normalization
Appetite normalizes (not suppressed). Blood sugar stabilizes. You notice improved energy and reduced food noise without constant hunger suppression.
Metabolic Improvements
Cardiovascular and inflammatory markers begin improving. Lab work shows positive metabolic shifts.
Maintenance Protocol
Micro-dose GLP-1 is designed as a sustained, ongoing protocol — not a short-term intervention. You maintain benefits with minimal side effects.
A complete micro-dose program.
Physician consultation
Licensed provider reviews your health profile and determines the right micro-dose protocol and compound for you.
Compounded semaglutide or tirzepatide
Choice of either compound in micro-dose vials (0.1–0.5mg), prepared by a licensed compounding pharmacy.
Supplies & syringes
Everything you need for safe self-administration: syringes, alcohol pads, storage guidance.
Personalized dose protocol
Your provider prescribes a customized dosing schedule based on your goals — titration or maintenance.
Ongoing provider support
Check-ins, dose adjustments, side effect management, and provider access throughout your protocol.
Safety & Considerations
Semaglutide and tirzepatide are prescription medications. Your Obsidian Genetics provider will review your full health history before prescribing.
⚠ Important Safety Information
Do not use semaglutide or tirzepatide if you or a family member have a history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Animal studies have shown a potential association between GLP-1 receptor agonists and thyroid tumors — the risk to humans is not yet fully established. These medications are also not recommended if you have a personal history of pancreatitis.
Frequently asked question
How is micro-dose GLP-1 different from standard semaglutide or tirzepatide?
Standard protocols target significant weight loss (1–2.4mg doses) and are designed for 3–6 month intensive treatment. Micro-dose GLP-1 uses sub-therapeutic doses (0.1–0.5mg) and is designed as an ongoing maintenance protocol for metabolic optimization, not weight loss. You retain all the systemic benefits of GLP-1 receptor agonism — blood sugar regulation, cardiovascular protection, anti-inflammatory effects, and emerging neuroprotective benefits — while avoiding the intense appetite suppression and GI side effects of higher doses.
Will I lose weight on micro dose?
Micro-dose GLP-1 is not designed for weight loss. Most patients on micro-dose protocols maintain stable weight. If you are overweight and seeking significant weight loss, a standard higher-dose protocol is more appropriate. Micro dose is ideal if you have reached your goal weight and want to maintain it with the metabolic and longevity benefits of GLP-1 agonism.
Can I switch from full-dose to micro-dose GLP-1?
Yes. Many patients complete a full-dose weight-loss protocol and transition to micro-dose for maintenance and longevity benefits. Your Obsidian Genetics provider will create a tapering schedule to safely transition you to your maintenance micro-dose, and continue supporting you through the adjustment.
Which compound should I choose — semaglutide or tirzepatide?
Both compounds are effective GLP-1 receptor agonists used in micro-dose protocols. Tirzepatide is a GIP/GLP-1 receptor agonist with a broader mechanism. Your Obsidian Genetics provider will recommend which compound best matches your health profile and goals. Some patients prefer one over the other based on tolerance or individual response — your provider can help determine the best fit.
Is micro-dose GLP-1 FDA-approved?
No. The branded semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) are FDA-approved for specific indications — weight loss and diabetes. Micro-dose protocols are off-label use, prescribed by a licensed provider and prepared by a licensed compounding pharmacy. This is a legal and common medical practice, but the low-dose protocol itself is not FDA-approved. Your provider will explain the off-label use and ensure it’s appropriate for your situation.
What are the longevity benefits of micro-dose GLP-1?
Research on full-dose GLP-1 receptor agonists shows benefits beyond weight loss: cardiovascular risk reduction (40% in the SELECT trial), improved kidney function, reduced inflammation, and emerging evidence for neuroprotective effects (relevant to Alzheimer’s and Parkinson’s disease research). These benefits appear to be dose-related — meaning they’re present across dosing ranges, not just at the highest doses. Micro-dose protocols capture these systemic benefits while maintaining a better quality of life with fewer side effects.
Important: Compounded semaglutide and tirzepatide are not FDA-approved drug products. Off-label micro-dose protocols are prescribed by a licensed healthcare provider and prepared by a licensed 503B or 503A compounding pharmacy. This product is not Ozempic®, Wegovy®, Mounjaro®, or Zepbound® (registered trademarks of their respective manufacturers). A licensed Obsidian Genetics physician will evaluate your health history and determine whether this medication and dosing protocol are appropriate for you. Prescription required. Individual results vary. Research statistics cited on this page reflect published clinical data on FDA-approved branded formulations — results with compounded formulations have not been independently verified by the FDA. References to cardiovascular, neuroprotective, and other systemic benefits are based on published clinical research and do not represent guaranteed outcomes of micro-dose therapy. Always disclose all medications, supplements, and health conditions to your provider. Do not use if you have a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).