Fat lost. Energy restored.
Muscle gained.
Body reimagined.
Three compounds. One unified protocol. Designed to shed fat without sacrificing muscle, energy, or the way you feel during the process.
GLP-1 alone works — but it has a cost. Energy drops. Muscle softens. Momentum fades. This stack was built to close that gap. Sermorelin restores the growth hormone signal that protects lean mass and drives recovery. NAD⁺ rebuilds the cellular energy system that caloric restriction depletes. The result: fat loss that doesn't leave you running on empty.
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Three signals. One coordinated result.
Each compound in this stack targets a distinct physiological pathway. Together, they create a layered system that addresses fat loss, muscle preservation, and energy — simultaneously and without conflict.
Metabolic Suppression
GLP-1 reduces appetite and slows gastric emptying, creating a sustained caloric deficit without willpower dependency. It modulates the hunger signal at its source — not the symptom.
GH-Axis Recovery
Sermorelin signals the pituitary to restore natural growth hormone pulses — preserving lean mass, accelerating tissue repair, and improving deep sleep while GLP drives the caloric reduction.
Cellular Energy Support
NAD⁺ fuels mitochondrial function and supports the cellular machinery that converts nutrients to usable energy — directly countering the fatigue that often accompanies active fat loss.
What's in this stack and why.
Every component is chosen for a specific role. There is no redundancy here — each compound addresses something the others cannot.
GLP-1
GLP-1 receptor agonists (semaglutide or tirzepatide) are the metabolic engine of this stack. By mimicking glucagon-like peptide-1, they suppress appetite at the hypothalamic level, slow the rate at which food leaves the stomach, and improve insulin sensitivity — creating a caloric deficit that doesn't require constant restraint.
In the context of this stack, GLP-1 handles the weight loss load while the other two compounds manage what GLP alone cannot: lean mass retention and sustained energy output.
Sermorelin
Sermorelin is a bioidentical analog of growth hormone-releasing hormone (GHRH). It works upstream — signaling your pituitary gland to release your own natural growth hormone in the same pulsatile rhythm your body was designed for.
In a fat loss context, this matters because GLP-1-driven caloric restriction can accelerate muscle loss if left unchecked. Sermorelin preserves lean tissue, improves recovery between training sessions, and enhances the quality of deep sleep — all of which compound the results of the fat loss phase.
NAD⁺
NAD⁺ (nicotinamide adenine dinucleotide) is a coenzyme central to how your cells produce usable energy. Levels decline with age and drop further during active caloric restriction. The result is a compounding fatigue that makes most weight loss protocols unsustainable.
By restoring NAD⁺ levels, this component directly addresses the energy deficit that GLP-1 therapy can create. The result is clearer mental focus, sustained physical output, and the metabolic resilience to stay consistent through the protocol.
What GLP-1 alone does — and what this stack does differently.
GLP-1 is a powerful tool. But weight loss without the right support costs you in ways you'll feel every day. This stack is designed to give your body everything it needs to lose fat and come out the other side stronger, sharper, and better built.
GLP-1 Alone
GLP-1 + Sermorelin + NAD⁺
The Bottom Line
GLP-1 handles the fat loss. Sermorelin protects your muscle, improves your sleep, and drives recovery. NAD⁺ keeps your cellular engine running so none of it feels like a grind. This is what a complete protocol looks like — and your prescribing physician will tailor it specifically to you.
A protocol that builds on itself.
Results from this stack are progressive and compound over time. The first month is the foundation — the second and third are where the transformation becomes visible.
Calibration Phase
Active Loss Phase
Peak Performance Phase
Maintenance & Optimization
Built for people who've done the basics — and need more.
This is not a starter protocol. This is the stack for someone who has already tried diet and exercise, who is fighting biology rather than habit, and who wants a medically supervised approach that works with their physiology instead of against it.
Stack At a Glance
Protocol FAQs
Why do I need Sermorelin and NAD⁺ if GLP-1 already causes weight loss?
GLP-1 creates a caloric deficit — but it does not preserve muscle, support sleep quality, or sustain your energy levels. Most people on GLP-1 alone experience fatigue, lean mass loss, and a plateau as the body adapts. Sermorelin restores the growth hormone signal that protects muscle. NAD⁺ rebuilds the cellular energy system that GLP suppression can deplete. Together, they make GLP-1 work better, longer, and with fewer downsides.
Is this stack appropriate for women?
Yes. All three compounds in this stack are appropriate for both men and women. GLP-1, Sermorelin, and NAD⁺ have well-established safety profiles across genders. Your prescribing physician will review your health history and confirm the protocol is appropriate for your individual situation.
Do I need to do labs before starting this stack?
No prerequisite labs are required for this stack. As with all Obsidian Genetics protocols, your prescribing physician will review your intake health history. Labs may be recommended based on your specific situation, but they are not required to begin this protocol.
How do the injections work — is it a lot to manage?
GLP-1 is once weekly — the lowest-burden injection in the protocol. Sermorelin is nightly pre-bed (a small subcutaneous injection that takes under a minute). NAD⁺ is available as an injection or through IV administration. Your care team will walk you through injection technique and answer any questions during your onboarding consultation.
Can I combine this stack with other Obsidian treatments?
Stacks should not be combined with other stacks or treatments that contain the same compounds. If you are already on GLP-1, Sermorelin, or NAD⁺ through an existing Obsidian plan, speak with your care team before adding this protocol. Your physician will assess for any overlap before prescribing.
This stack, prescribed
for you specifically.
Every Obsidian protocol is reviewed and prescribed by a board-certified physician based on your health history, goals, and how your body is responding. This is not a subscription box. It is a medical protocol.
Medical Disclaimer: This page is for informational purposes only and does not constitute medical advice. All treatments described are prescribed by licensed physicians based on individual patient health history and clinical evaluation. Results vary. These statements have not been evaluated by the Food and Drug Administration. Obsidian Genetics treatments are not intended to diagnose, treat, cure, or prevent any disease. Consult your prescribing physician before starting, stopping, or modifying any medical protocol.