Fat lost. Muscle held.
Nothing wasted.
Weight loss, done right.
Two compounds. One focused protocol. Designed to drive fat loss while protecting the lean mass you've worked to build.
GLP-1 is doing its job — the weight is coming off. But without something working alongside it, your body doesn't know the difference between fat and muscle. Sermorelin signals the pituitary to keep producing growth hormone, preserving lean tissue and improving recovery while GLP-1 handles the caloric reduction. Simpler than the full stack. More complete than GLP alone.
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Two signals. One synergistic result.
Each compound targets a distinct physiological pathway. Together, they create a coordinated system that addresses fat loss while preserving the lean mass you've worked to build.
Metabolic Suppression
GLP-1 reduces appetite and slows gastric emptying, creating a sustained caloric deficit without willpower dependency. It modulates the hunger signal at its source — not the symptom.
GH-Axis Recovery
Sermorelin signals the pituitary to maintain natural growth hormone pulses, preserving lean tissue and improving recovery while GLP-1 handles the caloric reduction.
What's in this stack and why.
Every component is chosen for a specific role. There is no redundancy here — each compound addresses something the other cannot.
GLP-1
GLP-1 receptor agonists are the metabolic engine of this stack. By mimicking glucagon-like peptide-1, they suppress appetite at the hypothalamic level, slow the rate at which food leaves the stomach, and improve insulin sensitivity — creating a caloric deficit that doesn't require constant restraint.
In this stack, GLP-1 handles the weight loss while Sermorelin ensures that loss is fat, not muscle.
Sermorelin
Sermorelin is a bioidentical analog of growth hormone-releasing hormone (GHRH). It works upstream — signaling your pituitary gland to release your own natural growth hormone in the same pulsatile rhythm your body was designed for.
In a fat loss context, this matters because GLP-1-driven caloric restriction can accelerate muscle loss if left unchecked. Sermorelin preserves lean tissue, improves recovery between training sessions, and enhances the quality of deep sleep.
What GLP-1 alone does — and what this stack does differently.
GLP-1 is powerful for fat loss. But added muscle protection and recovery support make the difference between losing weight and transforming your body composition.
GLP-1 Alone
GLP-1 + Sermorelin
The Bottom Line
GLP-1 drives the fat loss. Sermorelin protects your muscle and drives recovery. This is what sustainable fat loss looks like — and your prescribing physician will tailor it specifically to you.
A protocol that compounds on itself.
Results from this stack are progressive and build over time. The first month establishes the foundation — weeks 4-8 is where you notice the difference.
Calibration Phase
Active Loss + Recovery Phase
Body Composition Shift
Maintenance & Reassessment
Built for people losing weight — the right way.
This is the stack for someone who is losing weight with GLP-1 but wants to ensure that loss is fat, not muscle. You train consistently and want your body to reflect that effort, not soften during a cut.
Stack At a Glance
Protocol FAQs
Why add Sermorelin if GLP-1 is already causing weight loss?
GLP-1 creates a caloric deficit, but it doesn’t preserve muscle. Most people on GLP-1 alone experience lean mass loss because the body breaks down tissue for energy during caloric restriction. Sermorelin signals your pituitary to maintain natural growth hormone pulses — directly protecting lean tissue while you cut. This is what the difference between “losing weight” and “losing fat” really means.
How does this compare to Stack 01 (with NAD+)?
Stack 01 adds NAD+ for comprehensive cellular energy support. If you are primarily concerned about fat loss and muscle preservation — and your energy levels are stable — this stack (GLP-1 + Sermorelin) is simpler and more affordable. If you’re experiencing fatigue, low afternoon energy, or want maximum performance during your cut, Stack 01 is the complete approach. Your physician will help you choose based on your specific situation.
Is this appropriate for women?
Yes. Both GLP-1 and Sermorelin are appropriate for men and women. These compounds have well-established safety profiles across genders. Your prescribing physician will review your health history and confirm the protocol is appropriate for you.
Do I need labs before starting?
No prerequisite labs are required for this stack. Your prescribing physician will review your intake health history and medical background. Labs may be recommended based on your individual situation, but they are not required to begin.
How do I manage the injections?
GLP-1 is once weekly — the simplest part of the protocol. Sermorelin is a small nightly injection pre-bed and takes under a minute. Both are subcutaneous, meaning shallow injections into fatty tissue. Your care team will walk you through proper injection technique, and most people get comfortable with it quickly.
This stack, prescribed
for you specifically.
Every Obsidian protocol is reviewed and prescribed by a board-certified physician based on your health history, goals, and how your body is responding. This is not a subscription box. It is a medical protocol.
Medical Disclaimer: This page is for informational purposes only and does not constitute medical advice. All treatments described are prescribed by licensed physicians based on individual patient health history and clinical evaluation. Results vary. These statements have not been evaluated by the Food and Drug Administration. Obsidian Genetics treatments are not intended to diagnose, treat, cure, or prevent any disease. Consult your prescribing physician before starting, stopping, or modifying any medical protocol.