Fat lost. Testosterone restored.
Body rebuilt.
Total transformation.
Four compounds targeting fat loss, testosterone restoration, visceral fat reduction, and vascular performance simultaneously. The most comprehensive body transformation stack available.
This is not a starter protocol. It is the most comprehensive body transformation stack Obsidian offers — four compounds working across four distinct physiological pathways to address fat loss, hormonal optimization, body composition, and vascular function all at once. GLP-1 drives systemic fat loss. Enclomiphene stimulates the body's own testosterone production — restoring the hormonal environment that makes muscle growth, drive, and body composition possible. Tesamorelin targets visceral fat with clinical precision. Tadalafil supports blood flow and vascular performance. Because Enclomiphene affects hormonal pathways, lab work is required before prescribing. We provide everything you need.
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Four signals. Complete transformation.
Each compound in this stack targets a distinct physiological pathway. Together, they create a comprehensive system that addresses fat loss, hormonal restoration, visceral fat reduction, and vascular function all working in coordinated sync.
Metabolic Suppression
GLP-1 reduces appetite and slows gastric emptying, creating a sustained caloric deficit without willpower dependency. It modulates the hunger signal at its source — driving systemic fat loss while other compounds preserve muscle and hormonal function.
Testosterone Restoration
Enclomiphene stimulates the body's own LH and FSH production, naturally restoring testosterone levels without exogenous replacement. This restores the hormonal environment that makes muscle growth, drive, and body composition possible — without suppressing your own production.
Visceral Fat Targeting
Tesamorelin is a clinical-grade peptide specifically shown to reduce visceral adipose tissue — the metabolically active fat that other approaches cannot target. It works synergistically with GLP-1 to address fat loss at the deepest level.
Vascular Performance
Daily tadalafil support for blood flow and vascular function, delivering more of what the other compounds produce to every tissue. Optimized circulation amplifies the effects of fat loss, testosterone restoration, and body composition changes.
What's in this stack and why.
Every component is chosen for a specific role in total body transformation. There is no redundancy here — each compound addresses something the others cannot, creating the most comprehensive protocol available.
GLP-1
GLP-1 receptor agonists (semaglutide or tirzepatide) are the metabolic engine of this stack. By mimicking glucagon-like peptide-1, they suppress appetite at the hypothalamic level, slow gastric emptying, and improve insulin sensitivity — creating a caloric deficit that drives systemic fat loss.
In the context of this comprehensive stack, GLP-1 handles fat loss while Enclomiphene, Tesamorelin, and Tadalafil preserve muscle, restore hormones, target deep visceral fat, and optimize circulation.
Enclomiphene
Enclomiphene is a selective estrogen receptor modulator (SERM) that works upstream on your hypothalamic-pituitary-gonadal (HPG) axis. It stimulates your own production of LH and FSH, naturally restoring testosterone levels without suppressing your endogenous production.
In a transformation context, this matters because testosterone is essential for muscle growth, drive, and favorable body composition. By restoring it naturally, you maintain the hormonal environment that makes the rest of the stack work — and ensures your testosterone recovers post-protocol.
Tesamorelin
Tesamorelin is a growth hormone-releasing hormone (GHRH) analog that stimulates GH production specifically for the purpose of fat loss. Uniquely, clinical studies show it preferentially targets visceral adipose tissue — the metabolically active, inflammation-promoting fat that most diet and exercise approaches cannot address.
In this transformation stack, Tesamorelin complements GLP-1's systemic fat loss with clinical precision on visceral fat. The combination creates comprehensive fat loss without the muscle-wasting that GLP-1 alone can cause.
Tadalafil Daily
Tadalafil is a phosphodiesterase-5 inhibitor that supports vascular function and blood flow through smooth muscle relaxation. Daily dosing maintains consistent support for endothelial function and circulation, amplifying the delivery of what the other three compounds are producing.
In a transformation context, optimized blood flow means better oxygen availability, faster nutrient delivery to tissue, and enhanced delivery of hormonal signals throughout the body. It amplifies every effect of the stack and supports the cardiovascular system through intensive body composition change.
Partial Solutions vs. Total Transformation
Many approaches address one aspect of body composition. This stack addresses all of them simultaneously — fat loss, hormonal restoration, visceral fat targeting, and vascular function — creating the most comprehensive transformation possible.
Partial Solutions
Total Transformation
The Bottom Line
This is the most comprehensive transformation stack available. GLP-1 drives fat loss. Enclomiphene restores testosterone naturally. Tesamorelin targets visceral fat with clinical precision. Tadalafil optimizes circulation and vascular function. Together, they address every aspect of male body transformation simultaneously — and because Enclomiphene requires lab monitoring, your physician oversees the entire protocol with regular assessment.
A transformation that compounds over months.
Results from this stack progress across distinct phases. Labs are established first. Weeks 5-10 show hormonal restoration and fat loss activation. Weeks 11-20 show visible body composition shifting. By month 6+, total transformation is complete and hormonal optimization is sustained.
Lab Phase & Protocol Start
Restoration & Fat Loss
Visible Transformation
Total Transformation
For men ready for total transformation.
This is not a beginner protocol. This is the stack for someone who has tried diet and exercise, who understands that hormonal optimization is part of transformation, and who is ready to commit to labs and physician-supervised care for the most complete results.
Stack At a Glance
Common Questions
Why do I need labs for this stack?
Enclomiphene affects your hormonal pathways directly — it works on your hypothalamic-pituitary-gonadal axis to stimulate your own testosterone production. For safety and efficacy, your physician needs baseline lab work to assess your current hormonal state, ensure Enclomiphene is appropriate for you, and monitor your testosterone levels throughout the protocol. This is standard medical practice for any hormone-affecting treatment.
Is this stack only for men?
Yes. This stack has been specifically designed for men’s physiology and includes Enclomiphene, which works on the male HPG axis to restore testosterone production. This protocol is not appropriate for women. If you are a woman interested in a comprehensive transformation protocol, speak with your Obsidian physician about stacks tailored to female physiology.
What labs do I need, and how does Obsidian provide them?
Your physician will determine which labs are needed based on your health history — typically testosterone levels, estradiol, liver function, and general health markers. Obsidian Genetics will provide lab requisitions and direct you to a lab near you. All labs are arranged through your consultation, and costs are communicated upfront. You’ll have baseline labs before starting, and follow-up labs as your physician recommends.
How do I manage the injections?
Tesamorelin is a daily subcutaneous injection and takes under a minute. GLP-1 is once weekly. Enclomiphene and Tadalafil are oral, taken daily. Your care team walks you through proper injection technique during onboarding, and you’ll have full support throughout the protocol. Most patients find the routine straightforward after the first week.
Can I combine this stack with other protocols?
Stacks should not be combined with other stacks or treatments that contain the same compounds. This is the most comprehensive protocol available — combining it with other treatments could create redundancy or unsafe interactions. If you are already using any of these compounds, speak with your care team. Your physician will assess your situation and recommend the best approach.
What happens to my testosterone after the protocol ends?
Because you’re using Enclomiphene, not exogenous testosterone replacement, your body maintains its natural testosterone production capacity. Once you stop the protocol, your HPG axis continues to produce testosterone at the level your body has adapted to. Your physician will discuss post-protocol planning during your treatment, including any ongoing support you may want to maintain the benefits you’ve achieved.
Total transformation,
prescribed for you.
Every Obsidian protocol is reviewed and prescribed by a board-certified physician based on your health history, goals, and how your body is responding. This is not a supplement. This is a medical protocol with physician oversight and lab monitoring.
Medical Disclaimer: This page is for informational purposes only and does not constitute medical advice. All treatments described are prescribed by licensed physicians based on individual patient health history and clinical evaluation. Results vary. These statements have not been evaluated by the Food and Drug Administration. Obsidian Genetics treatments are not intended to diagnose, treat, cure, or prevent any disease. Consult your prescribing physician before starting, stopping, or modifying any medical protocol.