Total fat loss. Targeted. Energized.
The body recomposition stack.
Three compounds targeting fat loss from every angle — with a specific focus on stubborn visceral fat and the energy to push through the process.
GLP-1 drives systemic fat loss. But visceral fat — the deep abdominal fat that wraps your organs and drives metabolic dysfunction — often resists standard approaches. Tesamorelin is a growth hormone-releasing peptide with a specific clinical track record for visceral fat reduction. Combined with GLP-1 for overall caloric reduction and NAD⁺ for cellular energy, this stack attacks the fat that matters most while keeping you fueled and sharp through the process.
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Three signals. One coordinated result.
Each compound targets a distinct physiological pathway. Together, they create a layered system that addresses systemic fat loss, visceral fat specifically, and energy — simultaneously and without conflict.
Metabolic Suppression
GLP-1 reduces appetite and slows gastric emptying, creating a sustained caloric deficit without willpower dependency. It modulates the hunger signal at its source — not the symptom.
Enhanced Lipolysis
Tesamorelin specifically targets visceral adipose tissue, stimulating the GH axis to accelerate breakdown of deep abdominal fat. This is the fat that matters most for metabolic health.
Mitochondrial Support
NAD⁺ fuels mitochondrial function and keeps cellular energy output high while the other two compounds drive fat mobilization. No fatigue. No crashes. Pure sustained output.
What's in this stack and why.
Every component is chosen for a specific role. There is no redundancy here — each compound addresses something the others cannot.
GLP-1
GLP-1 receptor agonists are the systemic engine of this stack. By mimicking glucagon-like peptide-1, they suppress appetite at the hypothalamic level, slow gastric emptying, and improve insulin sensitivity — creating a caloric deficit that doesn't require constant restraint.
In this stack, GLP-1 handles the overall weight loss load while Tesamorelin focuses on the visceral fat problem specifically.
Tesamorelin
Tesamorelin is a growth hormone-releasing peptide (GHRP) with clinical evidence for preferentially targeting visceral adipose tissue — the deep abdominal fat that wraps organs and drives metabolic dysfunction.
While GLP-1 creates a caloric deficit, Tesamorelin accelerates the breakdown of the fat that matters most for your metabolic health and how you look in the mirror. This focused approach transforms the body composition.
NAD⁺
NAD⁺ (nicotinamide adenine dinucleotide) is a coenzyme central to cellular energy production. Levels decline with age and drop further during active caloric restriction. The result is compounding fatigue that makes protocols unsustainable.
By restoring NAD⁺ levels, this component keeps your cellular engine running clean and hot while your body is mobilizing fat. You maintain training intensity, mental clarity, and sustained output throughout the protocol.
What GLP-1 alone does — and what this stack does differently.
GLP-1 is powerful for systemic fat loss. But visceral fat often resists, energy crashes mid-cut, and training performance suffers. This stack solves all three problems simultaneously.
GLP-1 Alone
GLP-1 + Tesamorelin + NAD⁺
The Bottom Line
GLP-1 creates the deficit. Tesamorelin targets the fat that matters — visceral fat is the metabolic problem. NAD⁺ keeps your cellular engine running so you maintain training performance and mental clarity. This is the complete protocol for total body recomposition with metabolic health recovery.
A protocol that rebuilds you from the inside out.
Results from this stack are progressive and compound over time. The first month establishes the foundation — by month three you see the metabolic health shift.
Calibration + Visceral Mobilization
Visible Midsection Change
Significant Body Recomposition
Metabolic Health Recovery
Built for people fighting visceral fat.
This is the stack for someone who has lost weight with other protocols but still carries stubborn abdominal fat. Your metabolic health markers concern you. You want total fat loss with a specific focus on the visceral fat that drives metabolic dysfunction.
Stack At a Glance
Common Questions
How slow is "slow" with micro-dose GLP-1?
Micro-dose GLP-1 typically delivers 1-1.5 pounds of weight loss per week on average, compared to 2-3+ pounds per week with full-dose. This is steady, consistent progress that most people can maintain indefinitely without side effects. Your physician will tailor the dose based on your response and goals.
Why add Sermorelin if I'm still losing weight?
Sermorelin protects your lean tissue and ensures the weight you lose is fat, not muscle. Even at lower GLP-1 doses, your body needs support to preserve muscle during a caloric deficit. Sermorelin also improves sleep quality, which is critical for long-term sustainability and recovery.
Can I upgrade to full-dose GLP-1 later?
Yes. If you start with micro-dose and want to increase intensity later, you can work with your physician to adjust the protocol. Many people start with micro-dose to test tolerance, then increase if desired. This stack is flexible and tailored to your needs.
Is this appropriate for women?
Yes. Both micro-dose GLP-1 and Sermorelin are appropriate for men and women. These compounds have well-established safety profiles across genders. Your prescribing physician will review your health history and tailor the approach for you.
Do I need labs before starting?
No prerequisite labs are required. Your prescribing physician will review your intake health history. Labs may be recommended based on your individual situation, but they are not required to begin this protocol.
This stack, prescribed
for you specifically.
Every Obsidian protocol is reviewed and prescribed by a board-certified physician based on your health history, goals, and how your body is responding. This is not a subscription box. It is a medical protocol.
Medical Disclaimer: This page is for informational purposes only and does not constitute medical advice. All treatments described are prescribed by licensed physicians based on individual patient health history and clinical evaluation. Results vary. These statements have not been evaluated by the Food and Drug Administration. Obsidian Genetics treatments are not intended to diagnose, treat, cure, or prevent any disease. Consult your prescribing physician before starting, stopping, or modifying any medical protocol.