Longer. Stronger.
Immune to decline.
Longevity + immune defense.
Four compounds addressing the full spectrum of biological aging — cellular cleanup, immune modulation, energy restoration, and tissue recovery.
As we age, the immune system doesn't just weaken — it becomes dysregulated. Chronic low-grade inflammation accumulates. The body's ability to distinguish healthy tissue from damaged tissue becomes less precise. Low Dose Naltrexone (LDN) works at the immune system level, modulating inflammatory pathways and supporting immune homeostasis. Added to the core longevity stack of Rapamycin, NAD⁺, and Sermorelin, it completes a protocol that addresses every major mechanism of biological aging: cellular cleanup, immune regulation, energy production, and tissue repair.
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Four signals. Complete biological coverage.
Each compound targets a distinct mechanism of aging. Together, they address cellular damage, immune dysregulation, energy production, and tissue recovery — the full spectrum of what aging does to your body.
Cellular Cleanup
Rapamycin intermittently inhibits mTOR, triggering autophagy — your body's process of clearing out damaged cellular components and dysfunctional proteins that accumulate over decades.
Mitochondrial Support
NAD⁺ supports cellular energy through the cleanup phase and beyond, restoring mitochondrial efficiency that naturally declines with age — keeping your biological engine running clean and strong.
What's in this stack and why.
Every component is chosen for a specific role in the complete longevity protocol. Together, they address every major mechanism of biological aging.
Rapamycin
Rapamycin works by intermittently inhibiting mTOR, the cellular growth pathway. This triggers autophagy — the biological cleanup process that removes damaged cells, misfolded proteins, and accumulated cellular debris. When used intermittently, it's one of the most studied compounds for extended lifespan and improved healthspan in aging research.
The key to rapamycin's longevity benefit is that it is taken intermittently, not daily. This cycling approach activates the body's cleanup mechanisms without creating unwanted adaptation.
NAD⁺
NAD⁺ (nicotinamide adenine dinucleotide) is a coenzyme central to how your cells produce usable energy. It declines significantly with age, and this decline is one of the clearest biomarkers of biological aging. By restoring NAD⁺, you restore the cellular machinery that converts nutrients into ATP — the universal currency of cellular energy.
In this stack, NAD⁺ plays a critical supporting role: it keeps your mitochondria running efficiently while autophagy is being triggered by rapamycin.
Sermorelin
Sermorelin is a bioidentical analog of growth hormone-releasing hormone (GHRH). It signals your pituitary gland to release your own natural growth hormone in the same pulsatile rhythm your body was designed for — not mimicking constant high GH like some therapies, but restoring your body's natural pattern.
In a longevity context, this matters because GH maintains tissue quality, supports overnight recovery and deep sleep, and preserves lean mass. As GH naturally declines with age, this recovery signal becomes critical to maintaining physical and cognitive performance.
Aging Without Immune Support vs. With Full Longevity Stack
The difference between managing aging and managing it comprehensively shows up in both how long you live and how well you function during those years.
Aging Without Immune Support
With Full Longevity Stack
The Bottom Line
This is the most comprehensive longevity stack available. Rapamycin cleans house on a weekly cycle. NAD⁺ keeps the lights on. Sermorelin makes sure everything gets rebuilt. LDN balances the immune system so it protects you rather than accelerates aging. This is active longevity at the highest level. Your prescribing physician will tailor the protocol specifically to you.
A protocol that builds on itself.
Results from comprehensive longevity protocols compound over time. Early months establish the foundation. Later months and years show up as maintained performance, sustained immunity, and measurable biological markers.
Foundation Established
Immune Resilience & Energy Improve
Biological Aging Markers Trend Positive
Comprehensive Longevity Benefit Compounding
Built for comprehensive protection.
This is the most complete longevity protocol available. This is for someone who wants the most comprehensive protection against aging — someone who values immune resilience as highly as physical and cognitive performance.
Stack At a Glance
Common Questions
What is LDN and how is it different from regular naltrexone?
Low Dose Naltrexone (LDN) is naltrexone taken at a fraction of the standard pharmaceutical dose (typically 1.5-4.5mg versus 50mg). At these low doses, it activates different immune regulatory pathways rather than blocking opioid receptors. LDN reduces chronic inflammation and supports immune homeostasis — making it an ideal addition to a longevity protocol where immune dysregulation is a key driver of aging.
Why is rapamycin taken only once weekly?
Rapamycin works by intermittently inhibiting mTOR, and that intermittent cycling is what triggers the longevity benefit. Daily dosing would create continuous inhibition, which leads to tolerance and negates the autophagy signal. Once-weekly dosing creates the on-off cycle that your body responds to — cleanup happens, then recovery happens. This is how rapamycin is dosed in all longevity research protocols.
Is this stack appropriate for women?
Yes. All four compounds in this stack are appropriate for both men and women. Rapamycin, NAD⁺, Sermorelin, and LDN have well-established safety profiles across genders. Your prescribing physician will review your health history and confirm the protocol is appropriate for your individual situation.
Do I need to do labs before starting this stack?
No prerequisite labs are required for this stack. As with all Obsidian Genetics protocols, your prescribing physician will review your intake health history. Labs may be recommended based on your specific situation, but they are not required to begin this protocol.
Can I combine this stack with other Obsidian treatments?
Stacks should not be combined with other stacks or treatments that contain the same compounds. If you are already on Rapamycin, Sermorelin, NAD⁺, or LDN through an existing Obsidian plan, speak with your care team before adding this protocol. Your physician will assess for any overlap before prescribing.
Comprehensive longevity, prescribed
for your biology specifically.
Every Obsidian protocol is reviewed and prescribed by a board-certified physician based on your health history, goals, and how your body is responding. This is not a subscription box. It is a medical protocol.
Medical Disclaimer: This page is for informational purposes only and does not constitute medical advice. All treatments described are prescribed by licensed physicians based on individual patient health history and clinical evaluation. Results vary. These statements have not been evaluated by the Food and Drug Administration. Obsidian Genetics treatments are not intended to diagnose, treat, cure, or prevent any disease. Consult your prescribing physician before starting, stopping, or modifying any medical protocol.