Longer. Stronger.
Immune to decline.
Longevity + immune defense.
A vitality-focused protocol pairing cellular energy support, growth-hormone-releasing peptide therapy, and low-dose daily Tadalafil for vascular and endothelial benefit. Universal — appropriate for both men and women under physician oversight.
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What's in this stack — and why.
Three compounds, each addressing a different axis of vitality. They work in parallel: NAD⁺ powers the mitochondria, Sermorelin restores growth hormone and deep sleep, and low-dose daily Tadalafil keeps the vascular system primed for everything else to land.
NAD⁺
Nicotinamide adenine dinucleotide is a coenzyme required for energy production in every cell. Levels decline with age. Restoring NAD⁺ supports mitochondrial function, sirtuin activity, and cellular repair pathways — the metabolic foundation most longevity and vitality protocols build on.
In this stack, NAD⁺ keeps the energy floor steady while Sermorelin works on recovery and Tadalafil works on circulation.
Sermorelin
Sermorelin is a growth-hormone-releasing hormone (GHRH) analog. Rather than supplying synthetic growth hormone, it stimulates your pituitary to release GH naturally — preserving the body's own feedback loops. Most patients notice deeper sleep within the first few weeks, followed by improved recovery, body composition, and skin quality over months.
Because Sermorelin signals via the natural GHRH receptor, dosing is forgiving and side effects are typically mild compared to direct GH replacement.
Tadalafil (low-dose daily)
Tadalafil is a PDE5 inhibitor. At low daily doses (typically 2.5–5mg), it works as a vascular and endothelial support compound — improving nitric oxide signaling and peripheral blood flow. Beyond its better-known indication for men's sexual health, low-dose daily Tadalafil has emerging evidence in cardiovascular, lymphatic, and longevity contexts. Universal — appropriate for both men and women off-label, with physician oversight.
In this stack, Tadalafil's role is circulatory: helping the other compounds reach tissue, supporting recovery, and contributing to overall endothelial health.
Built for vitality.
The midlife professional
You're not sick — but your energy and recovery aren't what they were. This stack rebuilds the floor without aggressive intervention.
Endurance-oriented athletes
Vascular function is the bottleneck for long-duration output. NAD⁺ powers mitochondria, Tadalafil keeps blood flow on.
Longevity-focused users avoiding Rapamycin
If your cholesterol is high or you're on a statin, Rapa stacks aren't the right fit. This is the universal vitality alternative.
Anyone with poor sleep
Sermorelin's restoration of deep sleep architecture is what makes the rest of the protocol work. If you're not sleeping, start here.
Comprehensive longevity, prescribed
for your biology specifically.
Every Obsidian protocol is reviewed and prescribed by a board-certified physician based on your health history, goals, and how your body is responding. This is not a subscription box. It is a medical protocol.
Medical Disclaimer: This page is for informational purposes only and does not constitute medical advice. All treatments described are prescribed by licensed physicians based on individual patient health history and clinical evaluation. Results vary. These statements have not been evaluated by the Food and Drug Administration. Obsidian Genetics treatments are not intended to diagnose, treat, cure, or prevent any disease. Consult your prescribing physician before starting, stopping, or modifying any medical protocol.