Clean. Repair. Rebuild. Repeat.
The longevity stack.
Three compounds targeting the biological mechanisms of aging. Cellular cleanup, energy restoration, and recovery — running in a coordinated cycle.
Longevity isn't about living longer while feeling worse. It's about maintaining the biological capacity to perform, recover, and think clearly — year after year. Rapamycin works by intermittently inhibiting mTOR, the cellular growth pathway, triggering autophagy — your body's process of cleaning out damaged cells and dysfunctional proteins. NAD⁺ keeps mitochondria running efficiently through that process. Sermorelin maintains the GH signal that supports tissue quality and overnight repair. Together, they create a cycle: clean, fuel, rebuild.
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Three signals. One coordinated cleanup.
Each compound targets a distinct mechanism of aging. Together, they address cellular damage, energy production, and tissue recovery in a cycle that compounds over time.
Cellular Cleanup
Rapamycin intermittently inhibits mTOR, triggering autophagy — your body's process of clearing out damaged cellular components and dysfunctional proteins that accumulate over decades.
Mitochondrial Fuel
NAD⁺ supports cellular energy through the cleanup phase and beyond, restoring mitochondrial efficiency that naturally declines with age — keeping your biological engine running clean and strong.
Tissue Recovery
Sermorelin maintains the GH axis for ongoing tissue quality, deep sleep, and overnight repair — the foundational signals that keep your physical and cognitive capacity intact through the decades.
What's in this stack and why.
Every component is chosen for a specific role in the longevity cycle. Together, they address what aging does unchecked — and what sustained performance requires.
Rapamycin
Rapamycin works by intermittently inhibiting mTOR, the cellular growth pathway. This triggers autophagy — the biological cleanup process that removes damaged cells, misfolded proteins, and accumulated cellular debris. When used intermittently, it's one of the most studied compounds for extended lifespan and improved healthspan in aging research.
The key to rapamycin's longevity benefit is that it is taken intermittently, not daily. This cycling approach activates the body's cleanup mechanisms without creating unwanted adaptation. It works best when combined with strategies that fuel the cell while cleanup is happening — which is why it pairs perfectly with NAD⁺.
NAD⁺
NAD⁺ (nicotinamide adenine dinucleotide) is a coenzyme central to how your cells produce usable energy. It declines significantly with age, and this decline is one of the clearest biomarkers of biological aging. By restoring NAD⁺, you restore the cellular machinery that converts nutrients into ATP — the universal currency of cellular energy.
In this stack, NAD⁺ plays a critical supporting role: it keeps your mitochondria running efficiently while autophagy is being triggered by rapamycin. The result is that cellular cleanup happens without the energy collapse that often accompanies periods of stress or fasting.
Sermorelin
Sermorelin is a bioidentical analog of growth hormone-releasing hormone (GHRH). It signals your pituitary gland to release your own natural growth hormone in the same pulsatile rhythm your body was designed for — not mimicking constant high GH like some therapies, but restoring your body's natural pattern.
In a longevity context, this matters because GH maintains tissue quality, supports overnight recovery and deep sleep, and preserves lean mass. As GH naturally declines with age, this recovery signal becomes critical to maintaining physical and cognitive performance. Sermorelin is particularly effective when combined with cellular cleanup (rapamycin) and mitochondrial support (NAD⁺).
Aging Unchecked vs. Active Longevity Protocol
The difference between slowing aging and managing it proactively shows up not in how long you live — but in how well you perform during those years.
Aging Unchecked
Active Longevity Protocol
The Bottom Line
Rapamycin cleans house on a weekly cycle. NAD⁺ keeps the lights on so cleanup happens efficiently. Sermorelin makes sure everything gets rebuilt stronger than it was. This is active longevity — not fighting aging, but managing it proactively. Your prescribing physician will tailor the protocol specifically to you.
A protocol that builds on itself.
Results from longevity protocols compound over time. Early months establish the foundation. Later months and years show up as maintained performance and measurable biological markers.
Protocol Established
Energy & Recovery Baseline Improves
Cellular Health Markers Trending
Compounding Longevity Benefit
Built for the long view.
This is not a quick-fix protocol. This is the stack for someone who has studied aging research, who thinks about the next decade not the next month, and who wants a medically supervised approach to staying strong, sharp, and resilient as they age.
Stack At a Glance
Common Questions
Why is rapamycin taken only once weekly?
Rapamycin works by intermittently inhibiting mTOR, and that intermittent cycling is what triggers the longevity benefit. Daily dosing would create continuous inhibition, which leads to tolerance and negates the autophagy signal. Once-weekly dosing creates the on-off cycle that your body responds to — cleanup happens, then recovery happens. This is how rapamycin is dosed in all longevity research protocols.
Is this stack appropriate for women?
Yes. All three compounds in this stack are appropriate for both men and women. Rapamycin, NAD⁺, and Sermorelin have well-established safety profiles across genders. Your prescribing physician will review your health history and confirm the protocol is appropriate for your individual situation.
Do I need to do labs before starting this stack?
No prerequisite labs are required for this stack. As with all Obsidian Genetics protocols, your prescribing physician will review your intake health history. Labs may be recommended based on your specific situation, but they are not required to begin this protocol.
How complex is the dosing protocol?
The protocol is straightforward. Rapamycin is one dose on a consistent day each week. Sermorelin is a brief injection at bedtime. NAD⁺ is taken in the morning. Your care team will walk you through each component during onboarding and ensure you’re comfortable with the full protocol.
Can I combine this stack with other Obsidian treatments?
Stacks should not be combined with other stacks or treatments that contain the same compounds. If you are already on Rapamycin, Sermorelin, or NAD⁺ through an existing Obsidian plan, speak with your care team before adding this protocol. Your physician will assess for any overlap before prescribing.
This longevity stack, prescribed
for your biology specifically.
Every Obsidian protocol is reviewed and prescribed by a board-certified physician based on your health history, goals, and how your body is responding. This is not a subscription box. It is a medical protocol.
Medical Disclaimer: This page is for informational purposes only and does not constitute medical advice. All treatments described are prescribed by licensed physicians based on individual patient health history and clinical evaluation. Results vary. These statements have not been evaluated by the Food and Drug Administration. Obsidian Genetics treatments are not intended to diagnose, treat, cure, or prevent any disease. Consult your prescribing physician before starting, stopping, or modifying any medical protocol.